The Laboratory of Molecular Neurogenetics focuses on the understanding of the role of heritable disease-causing mutations in the manifestation of childhood cognitive dysfunction. We are seeking a highly motivated PhD candidate to be part of our group to undertake research as part of our NHMRC project (2016-2019).
One of our current genes of interest is a transcription factor encoded by the Aristaless-related homeobox (ARX) gene. Children with the two most common mutations (namely PA1 and PA2 mutation) all suffer from intellectual disability, with a proportion of them also with recurrent intractable seizures. Our current project plans to investigate whether the protective property of estradiol in PA1 mutation, as demonstrated by our collaborators, extends to the more common PA2 mutation. More importantly, we aim to uncover the molecular and cellular events that mediate the protection triggered by estradiol administration. Knowledge from this study will allow us to identify potential therapeutic treatments.
Successful applicant(s) must hold a degree of BSc (Hons) or equivalent/ AND have or expect to receive an APA or equivalent postgraduate scholarship that allows them to work in the field of biology.
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