Research Centre for Infectious Diseases

Eijkelkamp, B.A., Pederick, V.G., Plumptre, C.D., Harvey, R.M., Hughes, C.E., Paton, J.C., and McDevitt, C.A. The first histidine triad motif of PhtD is critical for zinc homeostasis in Streptococcus pneumoniae. (2015) Infection and Immunity doi: 10.1128/IAI.01082-15

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Congratulations to the 2015 RCID Honours students!
Erin Brazel & Amy Burns (McDevitt laboratory) and Stephen Johnson & Monique Smith (Beard laboratory) have all successfully completed their Honours year in the RCID. Great work everyone!

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Ms Stephanie Begg (McDevitt laboratory) has been awarded the 2015 Australian Federation of Graduate Women Barbara Hale Fellowship. Congratulations Stephanie.

The AFGW Barbara Hale Fellowship is worth $8,000 and will support Stephanie’s project, ‘Mapping the dynamic metalloproteome of Streptococcus pneumoniae at the host-pathogen interface to reveal novel antimicrobial targets.’ This is an extension of Stephanie’s PhD research, which aims to understand the role that essential micronutrients, such as metal ions, play in the colonisation and persistence of S. pneumoniae in humans. Streptococcus pneumoniae is the world’s foremost bacterial pathogen, with the greatest burden of disease in children under five years of age and the elderly, and the long-term aim of the research is to develop new drug targets against it.

 

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Amin Z, Harvey RM, Wang H, Hughes CE, Paton AW, Paton JC, Trappetti C. Isolation site influences virulence phenotype of serotype 14 Streptococcus pneumoniae strains belonging to multilocus sequence type 15. (2015) Infection and Immunity. 83:4781-90

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Sun S, Shi G, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates Iii JR, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. IRE1α is […]

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Kara EE, McKenzie DR, Bastow CR, Gregor CE, Fenix KA, Ogunniyi AD, Paton JC, Mack M, Pombal DR, Seillet C, Dubois B, Liston A, MacDonald KP, Belz GT, Smyth MJ, Hill GR, Comerford I, McColl SR. CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells. (2015) Nature Communications 6:8644.

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Robb, M., Robb, C.S., Higgins, M.A., Hobbs, J.K., Paton, J.C., Boraston, A.B. (2015) A second β-hexosaminidase encoded in the Streptococcus pneumoniae genome provides an expanded biochemical ability to degrade host glycans. J. Biol. Chem. doi:10.1074/jbc.M115.688630

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Congratulations to Dr Bart Eijkelkamp and Dr Christopher McDevitt for their successful Channel 7 Children’s Research Foundation grant to study “Optimal dietary metal ion uptake and its role in protection against childhood bacterial disease” for $35,000.

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Wielenga M.C., Colak S., Heijmans J., van Lidth de Jeude J.F., Rodermond H.M., Paton J.C., Paton A.W., Vermeulen L., Medema J.P., van den Brink G.R. (2015) ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy. Cell Reports doi:10.1016/j.celrep.2015.09.016

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Barnett TC, Cole JN, Rivera-Hernandez T, Henningham A, Paton JC, Nizet V, Walker MJ. Streptococcal toxins: role in pathogenesis and disease. (2015) Cell Microbiol. doi: 10.1111/cmi.12531.

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