Associate Professor Simon Koblar is a clinical neurologist, neuroscientist and teacher in both. He is Patron for Stroke SA and for the last 10 years has built the Stroke Research Programme as a collaboration between the University of Adelaide and The Queen Elizabeth Hospital.

 A/Prof Koblar’s major aims in Stroke research are:

(1) Brain Repair

(2) Molecular Pathology

(3) Genetics

(4) Prevention – Transient Ischaemic Attack.

His scientific impact and contribution may be assessed by the fact that he has published 46 peer-reviewed manuscripts that have had a total of 1,163 citations (IS Web of Knowledge 1996-2010). He publishes in a broad range of clinical and basic science journals and has had continued funding from a broad range of local, national and international funding sources.

In the last 10 years the SRP has made 3 significant discoveries that we aim to translate into clinical practice:

(1) they discovered a brain-specific transcription factor, the NPAS4 / Nxf gene in 2004, that is expressed in the stroke brain and may have a protective role

(2) they discovered the association between a variation in the Tissue Plasminogen Activator gene and risk for small-sized strokes (lacunar) in 2004

(3) they discovered that adult human Dental Pulp Stem Cells have a neural potential that may aid in brain repair following stroke.

 Research Interests

Stroke is by far the most common neurological disease and afflicts 60,000 Australians per annum. It is the second leading cause of death. A significant number of people are left with neurological disability and it remains the leading cause of adult disability in Australia.

The Stroke Research Programme (SRP) is a collaborative between the Schools of Medicine, Medical Science and Molecular Biomedical Science at the University of Adelaide and The Basil Hetzel Institute (BHI) of Medical Research, Dept of Neurology, Acute Stroke Unit at The Queen Elizabeth Hospital (TQEH).

Over the last 12 years the SRP has trained 20 PhD students, 18 Honours students and four Neurologists with a clinical and/or scientific interest in Stroke medicine.

Projects are being offered to students for honours, PhD and post-doctoral medical research www.adelaide.edu.au/srp/

Centre for Stem Cell Research

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