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Category: Research Highlight

Media Release: Uni of Adelaide researchers inducted into national healthy academy

Eight outstanding University of Adelaide researchers were inducted into the Australian Academy of Health and Medical Sciences at the inaugural Scientific Meeting, held in Canberra last night. The eight new Fellows from the University were among 77 inducted at the meeting, adding to the existing Fellowship of 131. New Fellows were drawn from all states […]

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Pregnancy in women with kidney disease

Female patients in the advanced stages of kidney failure are warned about the risk that pregnancy poses to mother and baby. For these women, becoming pregnant is unlikely, and if pregnancy occurs it can be medically challenging and complicated. So when Dr Shilpa Jesudason, who is a principal researcher in the Transplantation Group, began to assess the […]

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The role of Hyaluronan in chemotherapy resistance of ovarian cancer

Hyaluronan (HA) – a sugar molecule that is a major component of the extracellular matrix – is widely understood to bolster tumour growth as well as drug resistance to cancer. When Dr Carmela Ricciardelli was investigating the effect of chemotherapy on HA production in ovarian cancer cells, her findings were almost paradoxical: the cancer treatment was triggering […]

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Essential actions for macrophages in pregnancy

As part of her PhD, Dr Alison Care published illuminating new research identifying the role that macrophages – a specialised subset of immune cells – play in establishing successful pregnancy. Together with Professor Sarah Robertson and the Reproductive Immunology Group, Alison used a mouse model to demonstrate that the depletion of macrophages in early stages of pregnancy […]

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Visualising the surface of the lung to treat cystic fibrosis

A decade ago, Associate Professor David Parsons saw images of beetle airway walls generated by X-rays from a synchrotron and was intrigued by their definition and clarity. David, who is Chief Medical Scientist in the Department of Respiratory and Sleep Medicine at the Women’s and Children’s Hospital, wondered whether the synchrotron could be used to closely examine […]

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The impact of the parent’s sex on gene expression and fetal growth

Frequently, medical research challenges the veracity of lingering and relatively unsubstantiated ideas. Recent research has put one such dogma in the firing line: the longstanding notion that a person’s genetic make up is essentially a flip-of-a-coin, a battle between mum’s and dad’s genomes with dominant genes wiping out recessive ones. This research hints at a far […]

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A new understanding of mastitis

Lactation Mastitis affects around 25% of breastfeeding women inflicting serious flu-like symptoms such as fever and muscle fatigue. Until recently it was widely accepted that a bacterial infection in the breast caused mastitis and thus doctors prescribed antibiotics to women with the disease. However, when mammary gland biologist, Associate Professor Wendy Ingman began to read the […]

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Understanding and interpreting the origins of early intraventricular hemorrhage

Early intraventricular hemorrhage (IVH) can have lifelong consequences including abnormal neurodevelopment, cognitive impairment, and learning disorders. Preterm babies are at greater risk of early IVH in the first hours of life, a risk that heightens with lower birth weight and gestational age. Historically, understanding of how to identify those preterm babies at highest risk has been […]

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Arming the body’s police

The immune system is the bedrock of our health and when it is compromised the results can be catastrophic. Associate Professor Simon Barry, who is head of the Molecular Immunology Group, is mapping out a prototype of a healthy immune system, and is closely examining the function of regulatory T cells (Tregs), which play a crucial role in controlling immune function and […]

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Quality control in protein production ensures normal brain development

A precise control system known as non-sense mediated mRNA decay (NMD) exists in cells to make sure only top quality proteins are produced. In 2013 Professor Jozef Gecz and colleagues demonstrated that NMD plays a crucial role in normal brain development, and alterations in NMD genes were strongly associated with neurodevelopmental disorders. These findings suggest […]

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