We congratulate Dr Prabin Gyawali on being awarded his PhD and for receiving the Dean’s Commendation for Doctoral Thesis Excellence.
Dr Prabin Gyawali BSc, MSc, PhD
Thesis: Sex Hormone Binding Globulin – Regulation and role as a marker of chronic disease risk
Supervisors: Professor Gary Wittert, Dr Sean Martin, Professor Leonie Hielbronn
Summary: Until now Sex Hormone Binding Globulin (SHBG) has only been considered as predominantly a liver derived carrier protein to deliver sex hormones to target tissues and prevent their degradation. Given that the production of SHBG in the liver is influenced by metabolic, hormonal and nutritional factors, for his PhD, Prabin, a Clinical Biochemist, used epidemiological methods to identify a new function of SHBG – as a marker of poor health and chronic disease risk, particularly cardiovascular disease, Type II Diabetes and prostate cancer in men. For this he used biomedical and health data collected over time on men in the MAILES cohort study.
Impact: SHBG may be an early and easily measured marker for screening of pre-symptomatic chronic disease and outcomes. This epidemiological study now needs to be translated into an experimental clinical setting to examine the the usefulness of SHBG in screening for chronic disease. Given the strength of the results, however, Prabin advocates for routine measurement of SHBG when assessing men for cardiovascular disease.
We wish Prabin success in securing a post-doctoral position to allow him to continue his important work on SHBG, and wish him and his family all the best for the future. Email: firstname.lastname@example.org
- Gyawali P, Martin SA, Heilbronn LK, Vincent AD, Jenkins AJ, Januszewski AS, Adams RJT, O’Loughlin PD, Wittert GA.Higher Serum Sex Hormone-Binding Globulin Levels Are Associated With Incident Cardiovascular Disease in Men. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6301-6315. doi: 10.1210/jc.2019-01317. View abstract
- Gyawali P, Martin SA, Heilbronn LK, Vincent AD, Jenkins AJ, Januszewski AS, Taylor AW, Adams RJT, O’Loughlin PD, Wittert GA.Cross-sectional and longitudinal determinants of serum sex hormone binding globulin (SHBG) in a cohort of community-dwelling men. PLoS One. 2018 Jul 11;13(7):e0200078. doi: 10.1371/journal.pone.0200078. View abstract
- Gyawali P, Martin SA, Heilbronn LK, Vincent AD, Taylor AW, Adams RJT, O’Loughlin PD, Wittert GA.The role of sex hormone-binding globulin (SHBG), testosterone, and other sex steroids, on the development of type 2 diabetes in a cohort of community-dwelling middle-aged to elderly men. Acta Diabetol. 2018 Aug;55(8):861-872. doi: 10.1007/s00592-018-1163-6. Epub 2018 May 29. View abstract