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Freemasons Foundation Centre for Men’s Health (FFCMH) member Dr Arel Aref (PhD candidate and medical oncologist, Prostate Cancer Research Group, SAHMRI) with colleagues from the Centre, the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC), the Uni of Sydney, and Prof Peter Sutherland (senior Urologist) has published his first paper from his PhD research showing that the results of the most widely used test for prostate cancer may be affected by obesity.

In his research published in Endocrine Related Cancer, Adel examined data from 970 South Australian men from the Florey Adelaide Male Ageing Study, to determine the effects of obesity on prostate specific antigen (PSA) levels detected in blood and the influence of the sex steroid hormones, testosterone and estrogen.

Increases in PSA is an indication of inflammation, and consistently elevated levels of PSA in the blood can be an indicator of prostate cancer and lead to further diagnostic investigations.  PSA is also increased by the male sex steroid hormone, testosterone.

Adel and colleagues have shown that the concentration of PSA in the blood is lower in men who are obese (body mass index or BMI of 30 or higher) than in lean men, and that this can be attributed to lower concentrations of circulating testosterone.  The results of this study have implications for how we should interpret PSA levels in men who are obese and this is important given that 65% of men in Australia over the age of 25 are overweight or obese and this level is predicted to increase.  Further studies are now required to investigate effective strategies for applying this knowledge in clinical practice.

Adel’s supervisors from the FFCMH are Ass Professor Lisa Butler, Professor Gary Wittert and Dr Michael O’Callaghan.

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The Freemasons Foundation Centre for Men’s Health is pleased to announce that it is now a member of the Global Action on Men’s Health (GAMH).  GAMH is an initivae of the Men’s Health Forum (UK) and we thank the Men’s Health Forum, and in particular Peter Baker (DIrector), for inviting us to come on board. GAMH is backed by eight leading men’s health organisations intrnationally including the Australian Men’s Health Forum

The mission of GAMH is to create a world where all men and boys have the opportunity to achieve the best possible health and well-being wherever they live and whatever their backgrounds. As a member, the Centre encourages all of its researchers to
– promote GAMH wherever possible and represent it in a positive way,
– support GAMH’s position as an organisation that seeks to promote human rights and equality with respect to age, disability, sex, race, religion and belief, sexual orientation and gender assignment, and
–  fully endorse GAMH’s support for improving women’s health and its opposition to any activity on men’s health that might adversely affect women’s health, for example by reallocating funding.

The Centre looks forward to the greater engagement and education that this membership offers and looks forward to productive collaboration with other GAMH members across the globe.  We will keep our members up to date with the work of GAMH.  First up is GAMH’s new report http://gamh.org/hiding-in-plain-sight/.

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Untitled design (3)Congratulations to Centre members NHMRC ECR Dr Phillip Tully and Professor Deb Turnbull, and Associate Professor Nick Burns on being awarded a research grant to investigate dementia risk and preventative drug treatments.  The grant funding is provided for by the Alzheimer’s Drug Discovery Foundation (ADDF), USA.   The ADDF catalyses and funds drug discovery and drug development for Alzheimer’s disease and related disorders.  To learn more about the ADDF, visit the website at: www.alzdiscovery.org

The project is “Minimizing blood pressure variability with antihypertensive drugs to reduce dementia risk: an IPD meta-analysis of cohort studies in the CAPA consortium”

High blood pressure is the leading cause of death and disability worldwide and the leading modifiable risk factor for stroke and other cerebrovascular diseases. A very recent hypothesis in cardiology suggests that fluctuations in a person’s blood pressure over time are more strongly linked with stroke than a person’s blood pressure category (e.g. high, average, low). This variability in blood pressure may also impact dementia and vascular brain health, however, there have been very few studies so far on this topic. The aim of Dr Tully et al’s research is therefore to test whether fluctuations in blood pressure are associated with dementia and vascular brain health, and secondly, whether the use of certain blood pressure drugs can promote better cerebrovascular health. To achieve their aims they will bring together researchers from 10 different studies in the US, France and The Netherlands. By thoroughly investigating existing data from these studies, we will help answer questions about blood pressure and brain health, and inform decisions on the best strategy to reduce dementia risk.

 

 

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The Freemasons Foundation Centre for Men’s Health acknowledges SA Health for its ongoing commitment to the men’s health agenda here in South Australia. In April, Professor Paddy Phillips, Chief Medical Officer / Chief Public Health Officer at SA Health announced a new Men’s Health Ambassador, Robbie Gray, midfielder for the Port Adelaide Football Club.  Robbie came on board as […]

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Please join us for the June Men’s Health Research Lunchtime Seminar     Our speakers are: Ms Jessica Heatlie  PhD candidate (Uni of SA) “Movements of the androgen receptor and its role in the pathogenesis of prostate cancer” Ms Rayzel Fernadez  PhD candidate (Uni of Adelaide)  “A miR-194 regulated transcriptional network promotes prostate cancer metastasis” Mr Matthew […]

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Please join us for the May Men’s Health Research Lunchtime Seminar   Our speakers are: Ms Alison Barrett  Research Officer, iFarmwell project, University of South Australia Presentation:  “What farmers want: an exploration of Australian farmers’ online health and wellbeing intervention preferences” Mr Sonnay Uy  FFCMH Data Consolidation Officer Presentation: “Standard operating procedure for the FFCMH Data Repository – Stage […]

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                The FFCMH congratulates senior member Associate Professor Lisa Butler and co-Investigators on being awarded two year extension funding of $2Mi for theRevolutionary Team Award program on Lipids in Prostate Cancer from the Movember Foundation and the Prostate Cancer Foundation of Australia (PCFA). Professor Lisa Horvath, Medical Oncologist, from the Garvan Institute, […]

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Check your Engines: The FFCMH is one of a number of organisations partnering with Southern Cross Care this Men’s Health Week to promote men’s health and well-being in the community.  Two events will be held, where men (and family members) can come along and get some quick health checks and information; at the Philip Kennedy Centre, Largs Bay […]

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            We congratulate Dr Neil Jensen MBBS, FRACGP  on being installed as the new Grand Master of Freemasons of the jurisdiction of South Australia and Northern Territory, the highest honour in Freemasonry. The spectacular Grand Installation ceremony, steeped in tradition, was held on Apr 21 at the Entertainment Centre, attended by […]

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The Centre congratulates Associate Professor Nick Brook on being awarded the 2018 Freemasons Foundation Centre for Men’s Health’s Surgical and Research Travelling Fellowship generously sponsored by Mundipharma and AstraZeneca Australia, The Fellowship supports Fellows to undertake advanced overseas surgical training and related clinical research. A/Prof Brook’s fellowship will be for a period of 6 months, […]

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