National Institutes of Health (NIH): Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R21) 2015

This opportunity uses the R21 Exploratory/Developmental Research Grants funding mechanism.

This Funding Opportunity Announcement (FOA), encourages research projects focused on adducts to cellular macromolecules as indicators of exposures to cancer risk factors relevant to human populations. The priority is on projects that will focus on adductomic approaches, i.e., address some aspects of the totality of adducts. These projects should explore the basic aspects of adducts/adductomics that may have a potential utility in cancer detection, cancer prevention, and/or assessing cancer risks. The projects should be relevant to adducts in humans and human populations but may be conducted using various model systems (e.g., cultured cells, animals, etc.). The use of human biospecimens is encouraged and expected if appropriate but not required.

In well-justified cases, innovative studies using the adductomic approaches in the context of cancer etiology and/or gene-environment interaction research may also be appropriate. For projects intended for NIEHS support, the focus may be on innovative technology and method development.

Companion Schemes

Funding & Duration

Direct costs are limited to US $275,000 (AUD $377,000) over a two-year period, with no more than $200,000 (AUD $274,000) in direct costs allowed in any single year.

The proposed project period must not exceed 2 years.


Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.

Submission Requirements & Due Dates

  • 23 Oct 2015 – Letter of Intent (LOI) via Grants.Gov submission portal.
  • Copy of LOI forwarded to the Research Branch ASAP.
  • 9 Nov 2015 – full applications (by invitation only) submitted to the Research Branch for internal review.

Grants Officer: Dr Don McMaster


Further Information

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