National Institutes of Health (NIH): Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (U01) 2015

This opportunity uses the U01 Research Project – Cooperative Agreements funding mechanism.

This Funding Opportunity Announcement (FOA) encourages clinically-relevant translational/epidemiological research projects focused on the use of adducts to cellular macromolecules, as indicators of exposures to cancer risk factors in human populations and subgroups. The priority is on projects that will focus on adductomic approaches, i.e., address some aspects of the totality of adducts.

The projects are expected to be based on comprehensive use of human biospecimens for which detailed medical data are available (e.g., biospecimens from the NCI-supported cohort studies). The main emphasis of this FOA is on advancing the area of cancer detection, cancer prevention, and assessing cancer risks in human populations and subgroups. Nonetheless, studies evaluating the potential roles of adducts in cancer etiology for gene-environment interaction research may also be appropriate provided that such projects are based on appropriate sets of human biospecimens (such as specimens from cohorts studies supported by NIH).

Companion Schemes

Funding & Duration

Application budgets are not limited but need to reflect the actual needs of the proposed project. The project period may not exceed 5 years


Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.

Submission Requirements & Due Dates

  • 23 Oct 2015 – Letter of Intent (LOI) via Grants.Gov submission portal.
  • Copy of LOI forwarded to the Research Branch ASAP.
  • 9 Nov 2015 – full applications (by invitation only) submitted to the Research Branch for internal review.

Grants Officer: Dr Don McMaster


Further Information

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