Patient-Centered Outcomes Research Institute (PCORI): Pharmacological Treatment for Anxiety Disorders in Children, Adolescents, and/or Young Adults – Cycle 1 2018

The Patient-Centered Outcomes Research Institute (PCORI) seeks to fund high-quality clinical studies that compare the effectiveness of two or more pharmacological treatments for moderate to severe anxiety in children, adolescents, and/or young adults (e.g., comparisons of shorter-acting to longer-acting selective serotonin reuptake inhibitors (SSRIs) or comparisons of SSRIs to selective serotonin norepinephrine reuptake inhibitors (SNRIs)); pharmacological treatments should be delivered in conjunction with cognitive behavioural therapy (CBT) or another evidence-based psychological intervention.

PCORI is broadly interested in comparisons that are relevant and applicable to patients in the age range of 7 through 25 years; this age range represents a spectrum of developmental stages. Applicants will be asked to clearly define the specific age range to be studied, and to provide a scientific rationale justifying the coherence of the proposed study population, in terms of age, disease severity, proposed intervention approaches, and analytic plans.

Funding & Duration

The maximum direct project costs provided may be up to US $15M (approx. AUD $18.5M) for a maximum research period of 5 years.


Non-domestic (non-US) Entities (Foreign Institutions) are eligible to apply, as long as there is demonstrable benefit to the US healthcare system and US efforts in the area of patient-centered research can be shown clearly.

Organisations may submit multiple applications for funding. Individuals are not permitted to apply.

Submission Requirements & Due Dates

Further Information

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