US Department of Defense (DoD): Preemptive Expression of Protective Alleles and Response Elements – Funding Program

The US Department of Defense (DoD), via the Defense Advanced Research Projects Agency, invites proposals for its call on preemptive expression of protective alleles and response elements. This aims to develop programmable gene modulators (PGMs) for humans that can provide specific, effective, safe and transient medical countermeasures (MCMs) and prophylaxes to combat chemical, biological, radiological or nuclear threats. PGM-MCMs should be designed in a manner that enables somatic interventions at common pathway nodes to enhance protective host responses across multiple threats, promote universal neutralisation of viral threats, and be easily re-targeted and reconfigured for rapid adaptation and response to new and emergent threats.

The four primary threats that the programme will address are:

  • influenza viral infection;
  • opioid overdose;
  • organophosphate poisoning;
  • exposure to gamma radiation.

Funding & Duration

Multiple awards are anticipated. The amount of resources made available under this announcement will depend on the quality of the proposals received and the availability of funds.

Projects are supported for four years.


US and foreign for-profit and non-profit organisations and public and private organisations may apply.

Submission Requirements & Due Dates

Further Information

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