US NIH National Institute on Aging: Analyses of Adherence Strategies and Data Sets from CALERIE to Explore Behavioral and Psychosocial Aspects of Sustained Caloric Restriction in Humans (R21 Clinical Trial Not Allowed)

This opportunity uses the R21 Exploratory/Developmental Research Grant Award funding mechanism.

Funding Opportunity Announcement (FOA) Number: PA-18-826

Applications are invited for research projects (R01) involving secondary analyses of data in the Computerized Tracking System (CTS) database from the CALERIE (Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy) trial, to explore behavioural and psychosocial aspects of sustained caloric restriction (CR) in humans, including the translation of the CR adherence strategies used in the trial to promote healthy behaviours, especially for the prevention of weight gain with age.

CALERIE was the first trial in humans to specifically focus on the effects of sustained CR. It demonstrated feasibility of sustained human CR (for at least two years) and favorable effects on predictors of longevity, as well as on cardiometabolic risk factors. The sustained weight loss in CALERIE has not been previously attained in any clinical study in non-obese individuals.

Companion Schemes

  • PA-18-825, R01 Research Project Grant

Funding & Duration

The combined budget for direct costs for the two-year project period may not exceed USD $275,000 (approx AUD $369,000). No more than $200,000 (approx AUD $269,000) may be requested in any single year.


Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.

Submission Requirements & Due Dates

Further Information

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