US National Institutes of Health: Global Brain and Nervous System Disorders Research Across the Lifespan (R21 Clinical Trial Optional)

This opportunity uses the R21 Exploratory/Developmental Research Grants funding mechanism.

This Funding Opportunity Announcement (FOA) encourages exploratory applications for the development of innovative, collaborative research projects on brain and other nervous system function and disorders throughout life, relevant to low- and middle-income countries (LMICs). This includes but is not limited to neurological, mental, behavioural, alcohol and substance use disorders and spans the full range of science from basic to implementation research. Collaborations may be proposed between investigators in the United States (U.S) and any LMIC or between upper-middle income country (UMIC) investigators and their partners in any other LMIC.

These developmental/exploratory research grants are expected to prepare the foundation for more comprehensive research programs that enrich the knowledge base and contribute to the long-term goals of sustainable strengthening of research capacity in LMICs to:

  1. address nervous system development, function and impairment throughout life and
  2. lead to diagnostics, prevention, treatment and implementation strategies.

The proposed work may also contribute to developing a base for research networking and for evidence-based policy beyond the specific research project.

Companion Schemes

  • PAR-18-83 – Research Project Grant  (R01)

Funding & Duration

Application budgets are limited to USD $125,000 (approx. AUD $169,000) per year in direct costs, but must reflect the actual needs of the proposed project.

The project period may be up to 2 years.


Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.

Submission Requirements & Due Dates

Further Information

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