National Institute of Mental Health: New Computational Methods for Understanding the Functional Role of DNA Variants that are Associated with Mental Disorders

The purpose of this award is to support the development of advanced computational, bioinformatic and statistical tools, to determine the functional relevance of genetic variants associated with mental disorders of complex etiologies identified through genome-wide association or sequencing studies.

The overarching goal of this initiative is to support the development of innovative computational methods that facilitate the elucidation of the functionality of genetic variants associated with mental illness, taking into account the added complexities and nuances of brain diseases, and to ultimately inform novel treatment development based on human biology.

Funding Mechanisms

R01 – Research Project Grant – Collaborative (Clinical Trials Not Allowed)

This opportunity should be used when two or more sites are needed to complete the study. For a linked set of collaborative R01s, each site must have its own Program Director/Principal Investigator and the set of linked applications provide a mechanism for cross-site coordination, quality control, database management, statistical analysis, and reporting.

R01 – Research Project Grant – Standard (Clinical Trials Not Allowed)

To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing their specific interest and competencies.

Funding & Duration

Application budgets are not limited but need to reflect the actual needs of the proposed project, and the scope of the proposed project should determine the project period. The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

The maximum project period is five years.


US and foreign for-profit and non-profit organisations and public and private organisations may apply.

Submission Requirements & Due Dates

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