US NIH National Institute on Drug Abuse: Neuroscience Research on Drug Abuse (R01 & R21 Clinical Trial Options)

  • Please note: multiple due dates according to mechanism.
  • Check Submission Requirements & Due Dates for details.

About this Program

This scheme supports research to understand the neurobiological mechanisms underlying substance use disorders, with special emphasis on identifying changes and neuroadaptations that occur during dependence, withdrawal and relapse to chronic substance abuse. Basic neurobiological studies are encouraged that use in vivo and in vitro model systems as well as studies in humans. Applicants are especially encouraged to include appropriate behavioural models and paradigms of behavioural components or stages of addiction in their research proposals, especially in response to chronic exposure to drugs, different drug administration regiments, withdrawal or recovery.

(R01 Clinical Trial Optional)

(R21 clinical trial optional)

  • Funding & Duration: Direct costs are limited to USD $275,000 (approx. AUD $382,000) over a two-year period, with no more than USD $200,000 (approx. AUD $278,000) in direct costs allowed in any single year.
  • Further Information about the R21 Exploratory/Developmental Research Grants funding mechanism.
  • Visit the website for this scheme


Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply.

Submission Requirements & Due Dates

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