Pfizer Australia: Call for Proposals – Collaborative Research Projects

Pfizer Australia has issued the following Call for Proposals for research collaborations.

Modalities Considered

  • Large Molecules: antibodies, proteins, fusion proteins, antibody conjugates
  • Small Molecules: target classes include kinases, deubiquitinating enzymes, GPCRs, ion channels, solute transporters, and epigenetic targets

Disease Area Focus

  • Cancer: Select solid tumors, such as Colorectal, Breast, Lung, Pancreatic, Ovarian
  • Autoimmunity/Inflammation: IBD, NAFLD/NASH, Atopic Dermatology, Psoriasis
  • Metabolic: T2DM, Cachexia
  • Rare: ALS, Huntington’s, Duchene’s or Becker’s muscular dystrophy, non-malignant haematological disorders

Targets/Pathways Focus

  • Immune Activators /Enhancers (e.g., nucleic acid sensing, TLRs, etc.)
  • DNA Damage Recognition & Repair (e.g., replication stress or repair enzymes)
  • Tissue–Resident Immune modulation ( adaptive & innate, TME, organ specific, such as skin or gut)
  • Modulation of tumor cell heterogeneity, senescence, plasticity (including drug resistance)
  • Regulation of epithelial biology (i.e. restoring barrier health/integrity)
  • Modulation of fibrosis pathways either metabolism/stress-induced, or inflammation-induced (possibly tumor-driven)
  • Regulation of antigen-specific tolerance induction and/or modulation of T regulatory cells
  • Treatments for repeat expansion diseases including Huntington’s disease, ALS/FTD and myotonic dystrophy
  • Interventions to address skeletal and cardiac muscle diseases (including Duchenne or Becker muscular dystrophies)

Pre-Proposal Submission Details & Due Date

Pre-proposals must be submitted by 2 November 2018.

Submission entails a non-confidential 2-3 page overview of the target, mechanism, evidence for disease linkage, and the proposed therapeutic drug. At a high level, the pre-proposal should suggest how the therapeutic hypothesis could be tested in the clinic.

For additional information, contact:

Support with a Submission

Please contact Greg Macpherson, Business Partner Specialist, Research & Business Partnerships.

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